As in all other cartoons featuring the pair, Wile E. Coyote tries to catch the Road Runner. It begins with the Coyote (hungrii flea-baggius) assuming the "on your mark" stance used in track and field events. As soon as he goes into "get set" mode, he hears the familiar beeping sound and gets shocked into a backward move, suspended in mid-air atop a ravine. The Road Runner (tid-bitius velocitus) issues the gunshot that causes the Coyote to drop (one of three overhead shots shown in the short). The coyote's tools include a bow and arrow and a manhole cover suspended by rope and pulleys. Another tool is a rocket-powered Batman-type outfit that explodes on him and causes him to drop while his body is charred. Another trap involves iron pellets, a magnet, Roller skates and, unfortunately for Wile E., a locomotive. After that failure, the coyote sets up a spring-loaded block of pavement. At sunset, he erects a pair of machine guns connected by taut rope, and ends up getting reduced in size when the guns blast him in the midsection. That night, the coyote buys 30 miles of railroad tracks and a rocket sled, but instead of going straight ahead, the rocket sled shoots up into the sky, past many stars and satellites until it explodes in outer space, where it forms into a Sagittarius-like constellation of Wile E. Coyote.
The beginning of the cartoon when shown on CBS and ABC cuts the part where Wile E. Coyote falls after the Roadrunner fires off the starter pistol because that's when the opening credits appear (original opening credits of the Looney Tunes cartoons were cut for time reasons on ABC and CBS and replaced with a simple card with the title of the cartoon being shown before the cartoon). It should be noted that the CBS version edited the scene in a rather sloppy manner, because the scene abruptly changed to the next before Wile E. hit the ground, though the viewer could hear him hit the ground as he was walking away. ABC's version also cuts the gag where Wile E. sets up a machine gun trap and the Roadrunner breaks through the rope that trips the guns (which don't cause the guns to go off) and Wile E. pulls on the broken ropes and ends up getting shot in the midsection and cut down to size and an early gag where Wile E. Coyote is strapped into an elaborate rocket disguise that only succeeds in blowing him up and making him fall off the cliff.